Chemical name: Methoxypoly(ethylene glycol) ditetradecylacetamide

                           2-[(polyethylene glycol)-2000]-N,N ditetradecylacetamide;

 

Appearance: White to Yellow Solid

 

Solubility: DMF: 10 mg/ml;

                 DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; 

                 DMSO: Slightly Soluble; 

                 Ethanol: 1 mg/ml

 

Description: ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine that contains the active ingredient tozinameran.